1-氯-2,4-二硝基苯合成路线 （共 755 条）
反应条件
1: water; potassium hydroxide 2: alcoholic ammonium sulfide View Scheme
参考文献
Vermeulen
Recueil des Travaux Chimiques des Pays-Bas, 1906 , vol. 25, p. 17
反应条件
1: Et3N / ethanol / 4 h / Heating 2: 72 percent / hydrazine hydrate / Raney-Ni / ethanol; 1,2-dichloro-ethane / 3.5 h / 60 °C 3: 75 percent / tetrakis(acetonitrile)copper(I) tetrafluoroborate / toluene / 20 h / 80 - 90 °C 4: 95 percent / H2 / Raney-Ni / ethanol / 1 h / 760 Torr View Scheme
参考文献
Knapp, Spencer; Ziv, Joseph; Rosen, Joseph D.
Tetrahedron, 1989 , vol. 45, # 5 p. 1293 - 1298
反应条件
1: water; potassium hydroxide 2: alcoholic ammonium sulfide 3: glacial acetic acid View Scheme
参考文献
Vermeulen
Recueil des Travaux Chimiques des Pays-Bas, 1906 , vol. 25, p. 17
反应条件
ethanol; sodium ethanolate
参考文献
Horii
Yakugaku Zasshi, 1938 , vol. 58, p. 926,927; dtsch. Ref. S. 295
Chem.Abstr., 1939 , p. 2117
反应条件
sodium hydrogencarbonate in ethanol 6 h; Heating;
参考文献
McFarlane, Michael D.; Smith, David M.; Ferguson, George; Kaitner, Branko
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 893 - 902
参考文献
van der Kam
Recueil des Travaux Chimiques des Pays-Bas, 1926 , vol. 45, p. 732
参考文献
Hawthorne; Cram
Journal of the American Chemical Society, 1952 , vol. 74, p. 5859,5864
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
Title/Abstract Full Text Show Details
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: alcohol; Na2S2 2: Na2S; NaOH; diluted alcohol / Behandeln des entstandenen 2.4-Dinitro-thiophenols mit Chloressigsaeure View Scheme
参考文献
Claasz
Chemische Berichte, 1912 , vol. 45, p. 751
Chem. Zentralbl., 1913 , vol. 84, # I p. 865
参考文献
Eda, Masahiro; Kurth, Mark J.; Nantz, Michael H.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5131 - 5135
