1: acetonitrile With sodium hydride in 1,4-dioxane; water; acetonitrile; mineral oil T=20°C; 0.333333 h; 2: isobutyric acid ethyl ester in 1,4-dioxane; mineral oil T=20 - 55°C; 3: With water in 1,4-dioxane; mineral oil T=0°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/45496 A1, 2008 ;
Location in patent: Page/Page column 14 ;