1: With lithium diisopropyl amide in tetrahydrofuran T=-70 - 20°C; Inert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran pH=7; Cooling with ice;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: WO2009/55721 A2, 2009 ;
Location in patent: Page/Page column 84 ;
WO 2009/055721 A2