1-叔丁基-4-硝基-1H-吡唑合成路线 （共 5 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 72 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
nitric acid in sulfuric acid
T=0°C; 0.5 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC
Patent: WO2008/33999 A2, 2008 ;
Location in patent: Page/Page column 84 ;
反应条件
1: With sulfuric acid in 1,4-dioxane
T=20°C; 18 h;
2: With sodium hydrogencarbonate in 1,4-dioxane
参考文献
EXELIXIS, INC.; WILLIAMS, Matthew, A.
Patent: WO2012/61337 A1, 2012 ;
Location in patent: Page/Page column 48 ;
WO 2012/061337 A1
反应条件
triethylamine in methanol
T=80°C; 3 h;
参考文献
Nishiwaki, Nagatoshi; Ogihara, Takuma; Takami, Toshiko; Tamura, Mina; Ariga, Masahiro
Journal of Organic Chemistry, 2004 , vol. 69, # 24 p. 8382 - 8386
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=20°C; 3 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
