2-(N-甲基氨基)-6-甲基吡啶合成路线 （共 8 条）
反应条件
in methanol
T=140°C; 48 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/10794 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/010794 A1
反应条件
sodium tetrahydroborate in methanol
T=20°C; Condensation; hydrogenation; 48 h;
参考文献
Ferrarini, Pier Luigi; Mori, Claudio; Badawneh, Muwaffag; Calderone, Vincenzo; Greco, Rosamiria; Manera, Clementina; Martinelli, Adriano; Nieri, Paola; Saccomanni, Giuseppe
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 9 p. 815 - 826
反应条件
sodium tetrahydroborate in tetrahydrofuran
8 h; Heating; Yield given;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
1: ethanol / 5 h / 20 °C
2: NaBH4 / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
sodium amide; toluene
T=130°C;
参考文献
Tschitschibabin; Seide
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914 , vol. 46, p. 1232
Chem. Zentralbl., 1915 , vol. 86, # I p. 1065
反应条件
1: NaNH2; xylene
2: NaNH2; diethyl ether
View Scheme
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
反应条件
diethyl ether; sodium amide
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
参考文献
Tschitschibabin; Seide
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914 , vol. 46, p. 1232
Chem. Zentralbl., 1915 , vol. 86, # I p. 1065
