1.1: sodium hydride / tetrahydrofuran / 3 h / 0 °C 1.2: 1 h / 0 - 20 °C 2.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran / 0.05 h / -78 °C 2.2: 1 h / -78 - 20 °C View Scheme
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
1.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C 1.2: 1 h / 20 °C 2.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 0.05 h / -78 °C 2.2: 4 h / 20 °C View Scheme
参考文献
PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert
Patent: WO2012/158764 A1, 2012 ;
WO 2012/158764 A1
Buck; Ide
Journal of the American Chemical Society, 1932 , vol. 54, p. 3302,3308
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