反应条件
1: orthoformic acid triethyl ester; (S)-(-)-2-pyrrolidone-5-carboxylic acid With toluene-4-sulfonic acid in ethanol 4 h; Reflux; 2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 16 h;
参考文献
EXELIXIS, INC.; IBRAHIM, Mohamed, Abdulkader; JEONG, Joon, Won; JOHNSON, Henry William, Beecroft; KEARNEY, Patrick; LEAHY, James, W.; LEWIS, Gary, L.; NOGUCHI, Robin, Tammie; NUSS, John, M.
Patent: WO2010/45580 A1, 2010 ;
Location in patent: Page/Page column 87-88 ;
WO 2010/045580 A1