dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium hydrogencarbonate in tetrahydrofuran; water T=70°C; 48 h; Inert atmosphere;

manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide T=20°C; 18 h;

1: (3-bromophenyl)acetic acid methyl ester With tetrahydroxydiboron; ethanol; XPhos-Pd-G2; potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl T=80°C; Miyaura Borylation Reaction; 2 h; Inert atmosphere; 2: alpha-chloropyridine With potassium carbonate in water T=80°C; Suzuki Coupling; 15 h; Inert atmosphere;

1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 4 h; Inert atmosphereCooling with ice; 2: With zinc(II) chloride in tetrahydrofuran T=20°C; 2 h; Inert atmosphereCooling with ice; 3: methyl meta-chlorobenzoate Further stages;

palladium

in dichloromethane 10 h; Ambient temperatureIrradiation; Yield given. Yields of byproduct given;

Stille coupling;

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