2-溴甲基-3-硝基苯甲酸甲酯合成路线 （共 18 条）
反应条件
azobisisobutyronitrile in tetrachloromethane; hexane; dichloromethane
参考文献
Jagtap, Prakash; Southan, Garry; Salzman, Andrew; Szabo, Csaba; Ram, Siya
Patent: US2002/95044 A1, 2002 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
Kumiai Chemical Industry Co., Ltd.; Ihara Chemical Industry Co., Ltd.
Patent: US5534481 A1, 1996 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Reflux;
参考文献
Bayer Healthcare AG
Patent: US2010/10060 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane; cyclohexane
反应条件
in tetrachloromethane; ethyl acetate
反应条件
ammonia in methanol T=20°C; 2.5 h;
参考文献
NANJING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD.; YAN, Rong; YANG, Hao; XU, Yongxiang
Patent: WO2010/139266 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
反应条件
1: 99 percent / CHCl3 / 1 h / Heating 2: 92 percent / Et3N / CH2Cl2 / Ambient temperature 3: 100 percent / PPh3, CO / Pd(OAc)2 / acetonitrile / 23 h / 3040 Torr / Heating View Scheme
参考文献
Soederberg, Bjoern C.; Shriver, James A.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5838 - 5845
反应条件
1: 81 percent / ammonia / methanol / 2 h / 20 °C 2: 83 percent / ammonium formate / Pd/C / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Jagtap, Prakash G.; Southan, Garry J.; Baloglu, Erkan; Ram, Siya; Mabley, Jon G.; Marton, Anita; Salzman, Andrew; Szabo, Csaba
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 81 - 85
反应条件
1: With sodium carbonate in acetonitrile T=5°C; Inert atmosphereRefluxLarge scale; 2: With hydrogenchloride in water T=20 - 62°C; pH=< 6; 4 h; Large scale;
参考文献
CELGENE CORPORATION; LI, Ying; XU, Jean; KLOPFER, Kevin, J.
Patent: WO2013/126394 A1, 2013 ;
Location in patent: Paragraph 00123-00125 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 45°C; Product distribution / selectivity;
参考文献
RANBAXY LABORATORIES LIMITED; KAPOOR, Munish; KUMAR, Saridi, Madhava, Dileep; MURUGESAN, Balaguru; SATHYANARAYANA, Swargam; THAPER, Rajesh, Kumar; PRASAD, Mohan
Patent: WO2011/27326 A1, 2011 ;
Location in patent: Page/Page column 11 ;
