1-溴-2-甲氧基-3-硝基苯合成路线 （共 11 条）
反应条件
1: MFC(683)D02216 With potassium carbonate in N,N-dimethyl-formamide 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
Location in patent: Paragraph 00172 ;
反应条件
methanol T=100°C; 3 h; Autoclave;
参考文献
GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon
Patent: WO2010/125103 A1, 2010 ;
Location in patent: Page/Page column 78-79 ;
WO 2010/125103 A1
反应条件
potassium carbonate in acetone 24 h; Heating / reflux;
参考文献
Erickson-Miller, Connie J; Eppley, Daniel F.; Jenkins, Julian; Luengo, Juan I.; Liu, Nannan; Price, Alan T.; Shaw, Anthony N.; Visonneau, Sophie; Wiggall, Kenneth
Patent: US2004/19190 A1, 2004 ;
Location in patent: Page 18 ;
反应条件
nitric acid; acetic anhydride
参考文献
Journal of the American Chemical Society, , vol. 56, p. 1787,1790
反应条件
potassium carbonate; xylene
参考文献
Journal of the American Chemical Society, , vol. 56, p. 1787,1790
反应条件
1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C 2: potassium carbonate / acetone / 40 h / 70 °C View Scheme
参考文献
Journal of the Chemical Society, , vol. 73, p. 687
反应条件
ethanol; ammonia T=120°C;
参考文献
Meldola; Streatfeild
Journal of the Chemical Society, 1898 , vol. 73, p. 687
反应条件
ammonia; zinc in ethanol; water T=0 - 26°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/120003 A1, 2008 ;
Location in patent: Page/Page column 49-50 ;
WO 2008/120003 A1
反应条件
T=30°C; Rate constant;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 805 - 810
