1,2-二氯-4-硝基苯合成路线 （共 148 条）
反应条件
1: aqueous ethanol; Na2S 2: KMnO4; aqueous acetic acid 3: beim Erwaermen des Praeparats vom F:218grad mit Eisen und wss.Essigsaeure View Scheme
参考文献
Berg
Journal of the Chemical Society, 1949 , p. 1991
参考文献
Baker,B.R.; Ashton,W.T.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 1165 - 1170
反应条件
1: N,N-dimethyl-formamide / 20 - 100 °C 2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
THE UNIVERSITY OF HONGKONG; KAO, Yitsun, Richard; YANG, Dan; YEUN, Kwokyung
Patent: WO2011/15037 A1, 2011 ;
Title/Abstract Full Text Show Details
The University of Hong Kong
Patent: US2011/212975 A1, 2011 ;
反应条件
1: 97 percent / Et3N / dimethylformamide / 2 h / Heating 2: 84 percent / p-TsOH / 2 h / Heating View Scheme
参考文献
Xu, Zhenyuan; Du, Xiaohua; Gu, Jianbo
Organic Preparations and Procedures International, 2003 , vol. 35, # 4 p. 439 - 443
反应条件
1,3-bis-(diphenylphosphino)propane; potassium hydrogencarbonate; cobalt(II) chloride in para-xylene T=140°C; 4 h; Inert atmosphere; regioselective reaction;
参考文献
Toma, Gabriel; Yamaguchi, Ryohei
European Journal of Organic Chemistry, 2010 , # 33 p. 6404 - 6408
反应条件
1: 1.) NaH (60percent in oil) / 1.) DMSO, 2.) DMSO, 85 deg C, 24 h 2: 62 percent / SnCl2*2H2O, conc. HCl / acetic acid / 3 h / Heating View Scheme
参考文献
Sjogren, Eric B.; Rider, Michael A.; Nelson, Peter H.; Bingham, Stanford; Poulton, Anthony L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3295 - 3301
反应条件
potassium hydroxide; Aliquatreg; 336 in water; toluene T=60°C;
参考文献
WO2009/33581 A1, ;
Page/Page column 60 ;
反应条件
1: 1,2-dichloro-4-nitrobenzene; carbon monoxide; [PPN][Rh(CO)4] in tetrahydrofuran T=-78°C; Carbonylation; 0.5 h; 2: acetic anhydride in tetrahydrofuran T=-78 - 20°C; Acetylation;
参考文献
Journal of Organometallic Chemistry, , vol. 593-594, p. 109 - 118
反应条件
iodine T=110°C; 6 h;
参考文献
Du, Xiaohua; Zheng, Mei; Chen, Sheng; Xu, Zhenyuan
Synlett, 2006 , # 12 p. 1953 - 1955
反应条件
1: alcohol; ammonia 2: ueber 2-Chlor-4-nitro-benzoldiazoniumperbromid View Scheme
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 22 I, p. 823
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 23 I, p. 283 Anm.
