2-氨基-4-硝基苯酚合成路线 （共 142 条）
反应条件
1: triethylamine / tetrahydrofuran / 3 h / Heating
2: H2SO4 / xylene / 24 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Gorla, Suresh Kumar; Kavitha, Mandapati; Zhang, Minjia; Chin, James En Wai; Liu, Xiaoping; Striepen, Boris; Makowska-Grzyska, Magdalena; Kim, Youngchang; Joachimiak, Andrzej; Hedstrom, Lizbeth; Cuny, Gregory D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4028 - 4043
反应条件
1: triethylamine / tetrahydrofuran / 3 h / Heating
2: H2SO4 / xylene / 24 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
4: Et3N / tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
in ethanol
0.5 h; Ambient temperature;
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: oxygen; carbon / anhydrous xylene / 4 h / 120 °C / |Inert atmosphere
2: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 6 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Gorla, Suresh Kumar; Kavitha, Mandapati; Zhang, Minjia; Chin, James En Wai; Liu, Xiaoping; Striepen, Boris; Makowska-Grzyska, Magdalena; Kim, Youngchang; Joachimiak, Andrzej; Hedstrom, Lizbeth; Cuny, Gregory D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4028 - 4043
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
4: triethylamine / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
lead(IV) tetraacetate in ethanol; water; acetic acid
参考文献
E. R. Squibb and Sons, Inc.
Patent: US3985755 A1, 1976 ;
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
参考文献
De Meo; Pedini; Ricci; Bastianini; Sposini; Jacquignon
Farmaco, 1989 , vol. 44, # 5 p. 475 - 482
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
4: triethylamine / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
lead(IV) tetraacetate in dichloromethane; acetic acid
参考文献
E. R. Squibb and Sons, Inc.
Patent: US3985755 A1, 1976 ;
