2-氨基-4-硝基苯酚合成路线 （共 142 条）
参考文献
Cassella Aktiengesellschaft
Patent: US4329503 A1, 1982 ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=125°C; 3 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2005/23807 A2, 2005 ;
Location in patent: Page/Page column 63-64 ;
WO 2005/023807 A2
反应条件
hydrogenchloride; sodium hypochlorite; 4-(N,N-dimethlyamino)pyridine; palladium in 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; water
反应条件
1: triethylamine / tetrahydrofuran / 3 h / Heating 2: H2SO4 / xylene / 24 h / Heating 3: H2 / PtO2 / ethanol / 2585.7 Torr View Scheme
参考文献
BRANDEIS UNIVERSITY; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; HEDSTROM, Lizbeth, K.; CUNY, Gregory, D.; GORLA, Suresh, Kumar; KAVITHA, Mandapati
Patent: WO2014/28931 A2, 2014 ;
参考文献
Wang, Renchao; Xu, Jiaxi
Arkivoc, 2010 , vol. 2010, # 9 p. 293 - 299
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.166667 h; Inert atmosphere; 2: With sodium azide in water T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
Van Kalkeren, Henri A.; Te Grotenhuis, Colet; Haasjes, Frank S.; Hommersom; Rutjes, Floris P. J. T.; Van Delft, Floris L.
European Journal of Organic Chemistry, 2013 , # 31 p. 7059 - 7066
反应条件
sodium acetate in ethanol 24 h;
参考文献
Bedernjak, Alexandre F.; Groundwater, Paul W.; Gray, Mark; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Anderson, Rosaleen J.
Tetrahedron, 2013 , vol. 69, # 39 p. 8456 - 8462
参考文献
Gen.Aniline Works
Patent: US2020651 , 1933 ;
Full Text Show Details
I.G.Farbenind.
Patent: DE620346 , 1932 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 22, p. 754,756
反应条件
in methanol Heating;
参考文献
Lagutkin, N. A.; Mitin, N. I.; Zubairov, M. M.; Zelentsov, V. V.; Nikolaeva, T. B.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 2 p. 113 - 116
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 2 p. 178 - 181
反应条件
1: (i) MeOH, (ii) H2O 2: H2 / Pd-C / methanol / Ambient temperature 3: aq. HCl / Heating View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
