2-氨基-4-硝基苯甲醚合成路线 （共 59 条）
反应条件
acetic acid in water
参考文献
American Home Products Corporation
Patent: US2002/26052 A1, 2002 ;
反应条件
in water T=20°C; 1.5 h;
参考文献
Wyeth
Patent: EP1268487 B1, 2003 ;
Location in patent: Page/Page column 72 ;
参考文献
GLAXO GROUP LIMITED; WITHERINGTON, Jason
Patent: WO2007/118852 A1, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/118852 A1
反应条件
phosphoric acid; water; orthoarsenic acid T=100°C;
参考文献
Yale; Bernstein
Journal of the American Chemical Society, 1948 , vol. 70, p. 254
反应条件
sulfuric acid; orthoarsenic acid T=120 - 123°C;
参考文献
Freyss; Paira
Chemisches Zentralblatt, 1903 , p. I, 35
反应条件
1,1-dimethylnitroethane; palladium diacetate in methanol T=25°C; 48 h;
参考文献
Joncour, Roxan; Susperregui, Nicolas; Pinaud, Noel; Miqueu, Karinne; Fouquet, Eric; Sotiropoulos, Jean-Marc; Felpin, Francois-Xavier
Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9291 - 9296
参考文献
Vink,J.A.J. et al.
Tetrahedron, 1972 , vol. 28, p. 5081 - 5087
反应条件
1: 98 percent / pyridine / 1.) 0 deg C, 30 min, 2.) room temperature, 4 h 2: 95 percent / H2 / Pt/C / dimethylformamide / 4 h / 20 °C / 5171.5 Torr View Scheme
参考文献
Denny, William A.; Cain, Bruce F.; Atwell, Graham J.; Hansch, Corwin; Panthananickal, Augustine; Leo, A.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 276 - 300
反应条件
1: methanol / 100 °C / beim folgenden laengeren Erhitzen des Reaktionsprodukts mit Acetanhydrid
2: concentrated hydrochloric acid
View Scheme
参考文献
Ingold; Ingold
Journal of the Chemical Society, 1926 , p. 1319
反应条件
sodium cyanoborohydride; acetic acid
T=0 - 20°C; 3 h;
参考文献
Lee, Hyu Ji; Lim, Soo Jeong; Oh, Seung Jun; Moon, Dae Hyuk; Kim, Dong Jin; Tae, Jinsung; Yoo, Kyung Ho
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1628 - 1631
