反应条件
1.1: NaOEt / tetrahydrofuran / 25 °C
2.1: LDA / tetrahydrofuran / -78 - 20 °C
2.2: 52 percent / tetrahydrofuran / -78 - 20 °C
3.1: 47 percent / K2CO3 / acetone / 2 h / Heating
4.1: 40 percent / ethane-1,2-diol / 72 h / 100 - 125 °C
View Scheme
参考文献
Hollick, Jonathan J.; Golding, Bernard T.; Hardcastle, Ian R.; Martin, Niall; Richardson, Caroline; Rigoreau, Laurent J. M.; Smith, Graeme C. M.; Griffin, Roger J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 18 p. 3083 - 3086
