反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 - 70 °C 2: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 3: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C 4: water; potassium carbonate / tetrahydrofuran; methanol / 2 h / 50 - 60 °C / |Large scale 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 4 h / 20 - 30 °C / |Large scale View Scheme
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Tsuboi, Hiroyuki; Hashimoto, Norio
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 179 - 184
