3-(噻吩-3-基)丙酸乙酯合成路线 （共 7 条）
反应条件
sodium hydroxide; water in ethanol T=20°C; 18 h;
参考文献
Despeyroux, Pierre; Frehel, Daniel; Schoentjes, Bruno; Van Dorsselaer, Viviane
Patent: US2006/52426 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
120 h;
参考文献
Moustrou, Corinne; Samat, Andre; Guglielmetti, Robert; Dubest, Roger; Garnier, Francis
Helvetica Chimica Acta, 1995 , vol. 78, p. 1887 - 1893
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
1: 88 percent / NaH / tetrahydrofuran / 0 deg C, 30 min; RT, 16 h
2: 100 percent / H2 / Pd/C / ethanol / 96 h / 60 °C / 760 Torr
View Scheme
参考文献
Moustrou, Corinne; Samat, Andre; Guglielmetti, Robert; Dubest, Roger; Garnier, Francis
Helvetica Chimica Acta, 1995 , vol. 78, p. 1887 - 1893
反应条件
toluene-4-sulfonic acid in cyclohexane
参考文献
Blanchetiere, D.; Noyere, C.; Catel, J.; Andrieu, C. G.; Ebel, M.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 91, # 1-4 p. 93 - 102
反应条件
1: DIBAH / toluene / 4 h / -70 °C
2: 1.) n-BuLi / 1.) THF, hexane, -30 deg C, 45 min, 2.) THF, -30 to -10 deg C, 90 min
View Scheme
参考文献
Weyerstahl, Peter; Schenk, Anja; Marschall, Helga
Liebigs Annalen, 1995 , # 10 p. 1849 - 1854
反应条件
diisobutylaluminium hydride in toluene
T=-70°C; 4 h; Yield given;
参考文献
Weyerstahl, Peter; Schenk, Anja; Marschall, Helga
Liebigs Annalen, 1995 , # 10 p. 1849 - 1854
