1: With formic acid in water T=98°C; 20 h; 2: With hydrogenchloride in isopropyl alcohol T=10 - 60°C; pH=1 - 1.5; 2 - 2.5 h;

1: 1-[2-amino-1-(4-methoxyphenyl)ethyl]-cyclohexanol hydrochloride With sodium hydroxide in methanol T=0 - 5°C; pH=9 - 9.5; 0.5 h; 2: formaldehyd With formic acid in water T=20 - 100°C; 14 - 15 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;

hydrogenchloride in ethanol; ethyl acetate T=68 - 73°C; pH=2.5;

1: With formic acid in water T=95 - 100°C; 2: With sodium hydroxide in water pH=> 12; 3: With hydrogenchloride in water T=25 - 30°C;

1: With formic acid in water T=97 - 99°C; 16 h; 2: With hydrogenchloride in isopropyl alcohol T=10°C; pH=2.0; 1 - 2 h;

1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran T=0 - 5°C; 1 - 1.5 h; 2: (1-hydroxy-cyclohexyl)-(4-methoxy-phenyl)-acetonitrile in tetrahydrofuran T=0 - 40°C; 5 - 6.5 h; 3: formaldehyd; formic acid With hydrogenchloride Product distribution / selectivity; more than 3 stages;

1: With formic acid; hexamethylenetetramine in water T=20 - 102°C; 0.25 h; 2: With sodium hydroxide in water T=15 - 20°C; pH=10 - 11; Product distribution / selectivity;

1.1: sodium methylate / methanol / 2 h / 0 - 5 °C / Large scale reaction 1.2: 4 h / 0 - 5 °C / Large scale reaction 2.1: hydrogen / 3 h / 55 °C / 7500.75 - 9000.9 Torr / Large scale reaction 3.1: formic acid / water / 22 h / 100 °C / Large scale reaction 4.1: hydrogenchloride / water; isopropyl alcohol; toluene / 2 h / 0 - 5 °C / pH 3 - 4.5 / Large scale reaction View Scheme

1: hydrogen / 3 h / 55 °C / 7500.75 - 9000.9 Torr / Large scale reaction 2: formic acid / water / 22 h / 100 °C / Large scale reaction 3: hydrogenchloride / water; isopropyl alcohol; toluene / 2 h / 0 - 5 °C / pH 3 - 4.5 / Large scale reaction View Scheme

1.1: sodium methylate / methanol / 2 h / 0 - 5 °C / Large scale reaction 1.2: 4 h / 0 - 5 °C / Large scale reaction 2.1: hydrogen / 3 h / 55 °C / 7500.75 - 9000.9 Torr / Large scale reaction 3.1: formic acid / water / 22 h / 100 °C / Large scale reaction 4.1: hydrogenchloride / water; isopropyl alcohol; toluene / 2 h / 0 - 5 °C / pH 3 - 4.5 / Large scale reaction View Scheme