3-溴-4-氯吡啶1-氧化物合成路线 （共 4 条）
反应条件
1: With hydrogenchloride in methanol
T=0 - 20°C; 7 - 10 h;
2: With sodium hydroxide in water
参考文献
GLENMARK PHARMACEUTICALS, S.A.
Patent: WO2008/142542 A2, 2008 ;
Location in patent: Page/Page column 20 ;
WO 2008/142542 A2
反应条件
hydrogenchloride in methanol
T=22 - 26°C; 2 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
Location in patent: Page/Page column 36 ;
反应条件
1: acetic acid; dihydrogen peroxide / water / 16.5 h / 10 - 26 °C / |Reflux
2: sulfuric acid; potassium nitrate / 12 h / 110 °C
3: hydrogenchloride / methanol / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
反应条件
1: sulfuric acid; potassium nitrate / 12 h / 110 °C
2: hydrogenchloride / methanol / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
