6-溴-2,2-二甲基-4-二氢色原酮合成路线 (共 11 条)
反应条件
pyrrolidine in toluene 24 h; Heating;
参考文献
Breschi, Maria C.; Calderone, Vincenzo; Martelli, Alma; Minutolo, Filippo; Rapposelli, Simona; Testai, Lara; Tonelli, Federica; Balsamo, Aldo
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7600 - 7602
反应条件
trifluoroacetic acid in acetone; benzene
参考文献
US5958954 A1, ;
US 5958954 A
反应条件
hydrogenchloride in acetone; toluene
反应条件
1: AlCl3 / 160 °C 2: pyrrolidine / methanol / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 614 - 621
反应条件
1: H2SO4 / 120 °C 2: AlCl3 / 160 °C 3: pyrrolidine / methanol / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 614 - 621
反应条件
sodium tetrahydroborate
参考文献
Kabbe, Hans-Joachim; Widdig, Arno
Angewandte Chemie, 1982 , vol. 94, # 4 p. 254 - 262
反应条件
1: NaBH4 / methanol / 0 - 20 °C 2: H2SO4 / 20 °C 3: aq. HCl / Heating View Scheme
参考文献
Khelili; Nguyen; Lebrun; Delarge; Pirotte
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 189 - 193
反应条件
1: sodium borohydride / methanol
2: 89 percent / potassium hydrogen sulfate / 100 - 125 °C / 10 Torr
View Scheme
参考文献
Clayton, Stephen E.; Guinot, Stephane G.R.; Hepworth, John D.; Wainwright, Mark
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 263 - 269
反应条件
1: T=70 - 110°C; 72 h; Inert atmosphereSealed tube;
2: With hydrogenchloride in water
pH=5; 1 h; Cooling with ice;
参考文献
ARRAY BIOPHARMA INC.; HUNT, Kevin, W.; RIZZI, James, P.; COOK, Adam
Patent: WO2011/72064 A1, 2011 ;
Location in patent: Page/Page column 56 ;
WO 2011/072064 A1
反应条件
potassium cyanide
T=70 - 110°C; 72 h;
参考文献
Gadwood, Robert C.; Kamdar, Bharat V.; Cipkus Dubray, Loretta A.; Wolfe, Mark L.; Smith, Michael P.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1480 - 1487