chromium(VI) oxide; sulfuric acid in acetic acid 2 h; Ambient temperature;

Multistep reaction;

1: 49 percent / KOH / ethanol / 7 h / 70 °C 2: 32 percent / hydroxylamine hydrochloride, NaOAc*3H2O / acetic acid / 12 h / 185 °C 3: m-chloroperoxybenzoic acid (MCPBA) / CH2Cl2 / 1 h / Ambient temperature 4: 1.17 h / 110 °C 5: 3 M aq. HCl / 1 h / 100 °C 6: 92 percent / CrO3, aq. H2SO4 / acetic acid / 2 h / Ambient temperature View Scheme

1: 32 percent / hydroxylamine hydrochloride, NaOAc*3H2O / acetic acid / 12 h / 185 °C 2: m-chloroperoxybenzoic acid (MCPBA) / CH2Cl2 / 1 h / Ambient temperature 3: 1.17 h / 110 °C 4: 3 M aq. HCl / 1 h / 100 °C 5: 92 percent / CrO3, aq. H2SO4 / acetic acid / 2 h / Ambient temperature View Scheme

1: 49 percent / KOH / ethanol / 7 h / 70 °C 2: 32 percent / hydroxylamine hydrochloride, NaOAc*3H2O / acetic acid / 12 h / 185 °C 3: m-chloroperoxybenzoic acid (MCPBA) / CH2Cl2 / 1 h / Ambient temperature 4: 1.17 h / 110 °C 5: 3 M aq. HCl / 1 h / 100 °C 6: 92 percent / CrO3, aq. H2SO4 / acetic acid / 2 h / Ambient temperature View Scheme

1: 1.17 h / 110 °C 2: 3 M aq. HCl / 1 h / 100 °C 3: 92 percent / CrO3, aq. H2SO4 / acetic acid / 2 h / Ambient temperature View Scheme