(2R)-环己基(羟基)乙腈合成路线 （共 19 条）
反应条件
1: With (S,S)-(salen derivative)titanium in dichloromethane; water; tert-butyl alcohol T=-40°C; 2: With candida antarctica lipase-B; isopropyl alcohol in various solvents T=20°C; 21 h; Title compound not separated from byproducts;
参考文献
Belokon, Yuri N.; Blacker, A. John; Clutterbuck, Lisa A.; Hogg, David; North, Michael; Reeve, Christopher
European Journal of Organic Chemistry, 2006 , # 20 p. 4609 - 4617
参考文献
Mori; Nitta; Kudo; Inoue
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4333 - 4336
反应条件
1: cyclohexanecarbaldehyde With sodium hydrogensulfite in diethyl ether; water T=20°C; 2 h; 2: sodium cyanide in diethyl ether; water T=20°C;
参考文献
Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran
Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630
反应条件
hydrogenchloride in diethyl ether
参考文献
Grunewald,G.L. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 10 - 16
反应条件
InI3; 1,1,3,3-tetramethyldisiloxane in dichloromethane T=20°C; 1 h;
参考文献
Inamoto, Yoshihiro; Nishimoto, Yoshihiro; Yasuda, Makoto; Baba, Akio
Chemistry Letters, 2013 , vol. 42, # 12 p. 1551 - 1553
反应条件
1: InI3 / dichloromethane / 0.05 h / 20 °C 2: InI3; 1,1,3,3-tetramethyldisiloxane / dichloromethane / 1 h / 20 °C View Scheme
参考文献
Inamoto, Yoshihiro; Nishimoto, Yoshihiro; Yasuda, Makoto; Baba, Akio
Chemistry Letters, 2013 , vol. 42, # 12 p. 1551 - 1553
反应条件
in water; ethyl acetate 5 h;
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Shiner, Mark A. R.; Benton, David C. H.; Dunn, Philip M.; Ayalew, Yeshi; Jenkinson, Donald H.
Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 8 p. 851 - 857
反应条件
1: 84 percent / HCl / dioxane / 24 h / 20 °C
2: 75 percent / NaHCO3 / aliquat(R) 336 / toluene / 48 h
3: 26 percent / oxalyl chloride; DMSO; TEA / CH2Cl2 / -60 - 20 °C
4: 78 percent / conc. HCl; H2 / Pd/C / ethanol / 20 °C / atmospheric pressure
View Scheme
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Shiner, Mark A. R.; Benton, David C. H.; Dunn, Philip M.; Ayalew, Yeshi; Jenkinson, Donald H.
Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 8 p. 851 - 857
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 24 h;
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Thorpe, Andrew J.
Synlett, 2007 , # 8 p. 1211 - 1214
