2-(氯甲基)-3,5-二氧杂-1-己烯合成路线 （共 15 条）
反应条件
sodium t-butanolate
T=60°C; 3 h;
参考文献
Gu, Xue-Ping; Nishida, Nobuyuki; Ikeda, Isao; Okahara, Mitsuo
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3192 - 3196
反应条件
indium; ethylene dibromide in tetrahydrofuran; water
T=20°C;
参考文献
Maslak, Veselin; Tokic-Vujosevic, Zorana; Ferjancic, Zorana; Saicic, Radomir N.
Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6709 - 6711
反应条件
1: cycloheptanone With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=25 - 40°C;
2: 2-(chloromethyl)-3,5-dioxahex-1-ene in N,N-dimethyl-formamide; mineral oil
T=120°C;
参考文献
IRONWOOD PHARMACEUTICALS, INC.; JIA, James; MERMERIAN, Ara; KIM, Charles; LUNDRIGAN, Regina; MOORE, Joel
Patent: WO2010/39982 A1, 2010 ;
Location in patent: Page/Page column 113-114 ;
WO 2010/039982 A1
反应条件
indium; ethylene dibromide in tetrahydrofuran; water
T=20°C;
参考文献
Maslak, Veselin; Tokic-Vujosevic, Zorana; Ferjancic, Zorana; Saicic, Radomir N.
Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6709 - 6711
反应条件
bis-triphenylphosphine-palladium(II) chloride in benzene
react. mixt. washed (aq. KF); extn.of org. layer (ether); dried over MgSO4; product isolated by distn. (reduced pressure); acetonylated by chromy. (silica gel);
参考文献
Kosugi; Miyajima; Nakanishi; Sano; Migita
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 10 p. 3383 - 3385
