1: malonic acid dimethyl ester With triethylamine; magnesium chloride in toluene T=20°C; 2 h; 2: 5-fluoro-nicotinoyl chloride in toluene T=20°C;
参考文献
Thuring, Johannes Wilhelmus John F.; MacDonald, Gregor James; Grantham, Christopher James; Dinklo, Theodorus; Lesage, Anne Simone Josephine
Patent: US2011/269748 A1, 2011 ;
Location in patent: Page/Page column 23-24 ;