反应条件
1: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide With methyllithium; lithium chloride in tetrahydrofuran; formaldehyde diethyl acetal T=-78°C; Inert atmosphere; 2: n-butyllithium in tetrahydrofuran; formaldehyde diethyl acetal; hexane T=-78 - -40°C; Inert atmosphere; 3: allyl bromide in tetrahydrofuran; formaldehyde diethyl acetal; hexane T=-40°C; Inert atmosphere; optical yield given as percent dediastereoselective reaction;
参考文献
Kummer, David A.; Chain, William J.; Morales, Marvin R.; Quiroga, Olga; Myers, Andrew G.
Journal of the American Chemical Society, 2008 , vol. 130, # 40 p. 13231 - 13233
