溴丙酮酸合成路线

参考文献

Macdonald, Simon J. F.; Dowle, Michael D.; Harrison, Lee A.; Clarke, Geoffrey D. E.; Inglis, Graham G. A.; Johnson, Martin R.; Shah, Pritom; Smith, Robin A.; Amour, Augustin; Fleetwood, Gill; Humphreys, Davina C.; Molloy, Christopher R.; Dixon, Mary; Godward, Rosalind E.; Wonacott, Alan J.; Singh, Onkar M. P.; Hodgson, Simon T.; Hardy, George W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 3878 - 3890

1113-59-3溴丙酮酸+

115-11-7异丁烯

16754-73-73-溴-2-氧代丙酸叔丁酯

参考文献

Journal of the American Chemical Society, , vol. 127, # 18 p. 6563 - 6572

1113-59-3溴丙酮酸+

75-65-0叔丁醇

16754-73-73-溴-2-氧代丙酸叔丁酯

参考文献

Angewandte Chemie - International Edition, , vol. 51, # 52 p. 13109 - 13113
Angew. Chem., , vol. 124, # 52 p. 13286 - 13290,5

1113-59-3溴丙酮酸+

2196-13-6硫代异烟酰胺

21278-86-42-(4-吡啶基)噻唑-4-羧酸

参考文献

WO2004/41813 A1, ;

Page 111 ;
WO 2004/041813 A1

1113-59-3溴丙酮酸+

55-21-0苯甲酰胺

23012-16-02-苯基-4-噁唑羧酸

参考文献

Blau; Stuckwisch
Journal of Organic Chemistry, 1957 , vol. 22, p. 82

1113-59-3溴丙酮酸+

84863-83-22,3-二氯硫代苯甲酰胺

257876-07-62-(2,3-二氯苯基)-噻唑-4-羧酸

参考文献

Gillespie, Paul; Goodnow, Robert Alan; Kowalczyk, Agnieszka; Le, Kang; Zhang, Qiang
Patent: US2007/167622 A1, 2007 ;
Location in patent: Page/Page column 14 ;
US 20070167622 A1

1113-59-3溴丙酮酸+

89226-13-12-氨基-2-硫代乙基氨基甲酸叔丁酯

71904-80-82-[[(叔丁氧羰基)氨基]甲基]噻唑-4-羧酸

参考文献

Souto, Jose A.; Vaz, Esther; Lepore, Ilaria; Poeppler, Ann-Christin; Franci, Gianluigi; Alvarez, Rosana; Altucci, Lucia; De Lera, Angel R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4654 - 4667

1113-59-3溴丙酮酸+

6965-58-8

737822-96-7

参考文献

Shanghai Tangrun Pharmaceuticals, Co., Ltd.; Zhang, Suoming
Patent: US2014/163219 A1, 2014 ;
Location in patent: Page/Page column ;

1113-59-3溴丙酮酸+

391-12-87-三氟甲基靛红

924633-55-6

参考文献

Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64

1113-59-3溴丙酮酸+

121-45-9三甲氧基磷

4185-81-3

参考文献

Hirschbein, Bernard L.; Mazenod, Francois P.; Whitesides, George M.
Journal of Organic Chemistry, 1982 , vol. 47, # 19 p. 3765 - 3766