反应条件
1: 55 percent / Et2AlCl / CH2Cl2 / 15 h / Ambient temperature
2: 1) (+)-(S)-N,S-dimethyl-S-phenylsulfoximine, n-BuLi, 2) 2-methyl-1-propanol / 1) THF, -80 deg C, 1 h, 2) reflux
3: 92 percent / 37percent aq. HCl / CH2Cl2; methanol / 5 h / Ambient temperature
4: 1) LDA, TMSCl, 2) Pd(OAc)2 / 1) THF, -80 deg C, 1 h, 2) CH3CN, r.t., 5 h
5: 1) HMDS, n-BuLi, 2) AcOH / 1) THF/HMPT, -80 deg C, 1 h, 2) -80 deg C
View Scheme
参考文献
Quinkert, Gerhard; Grosso, Michael del; Bucher, Astrid; Bauch, Markus; Doering, Wolfgang; et al.
Tetrahedron Letters, 1992 , vol. 33, # 25 p. 3617 - 3620
