N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
sulfuric acid in dichloromethane
参考文献
Bulletin of the Chemical Society of Japan, , vol. 60, # 1 p. 249 - 254
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane; tert-butyl alcohol 4 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 30, # 49 p. 6859 - 6860
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in N,N-dimethyl acetamide T=55°C; 24 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 34, # 46 p. 7409 - 7412
反应条件
in benzene 0.833333 h; Heating;
参考文献
Synthesis, , # 2 p. 135 - 136
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 326, # 2 p. 266 - 272
反应条件
tetrahydrofuran; chloroformic acid ethyl ester; triethylamine anschliessend Behandeln mit L-Phenylalanin-methylester in wss. Dioxan und Behandeln des Reaktionsprodukts in Aceton mit wss. NaOH;
参考文献
Helvetica Chimica Acta, , vol. 41, p. 1273,1280
Helvetica Chimica Acta, , vol. 40, p. 614,620
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C 1.2: 17 h / 20 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C 3.1: palladium on carbon; hydrogen / methanol / 15 h / 20 °C / 760.05 Torr View Scheme
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
反应条件
1.1: thionyl chloride / dichloromethane / 0.25 h / 25 °C 1.2: 25 °C 2.1: triethylamine / acetonitrile; water / 12 h / 25 °C View Scheme
参考文献
Khatib, Mirna El; Elagawany, Mohamed; Caliskan, Eray; Davis, Emily Faith; Faidallah, Hassan M.; El-Feky, Said A.; Katritzky, Alan R.
Chemical Communications, 2013 , vol. 49, # 26 p. 2631 - 2633
反应条件
1: 94 percent / dicyclohexylcarbodiimide, HOBt / dimethylformamide / Ambient temperature 2: H2 / Pd/C / methanol / 6 h 3: diethyl phosphorocyanidate, Et3N / dimethylformamide / 16 h / Ambient temperature 4: H2 / Pd/C / methanol 5: diethyl phosphorocyanidate, Et3N / dimethylformamide / 16 h / Ambient temperature View Scheme
参考文献
Asagarasu, Akira; Uchiyama, Taketo; Achiwa, Kazuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 697 - 703
反应条件
1: triethylamine; toluene; chlorocarbonic acid isobutyl ester / anschliessend Behandeln mit L-Phenylalanin-aethylester und Behandeln des Reaktionsprodukts mit NH3 in Methanol 2: palladium; ethanol; acetic acid / Hydrogenation View Scheme
参考文献
Izumiya; Fruton
Journal of Biological Chemistry, 1956 , vol. 218, p. 59,70
