2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: 2-methyl-but-3-yn-2-ol With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=0°C; 0.5 h; 2: 6-hydroxy-quinoline With trifluoroacetic anhydride; copper(l) chloride in acetonitrile T=0°C; 3 h;
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: WO2005/90357 A1, 2005 ;
Location in patent: Page/Page column 325-326 ;
WO 2005/090357 A1
反应条件
1: 1) n-BuLi 2: Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 0.25 h / Ambient temperature 3: 1) Ph3SnH, AIBN, 2) KHCO3, 30percent H2O2 / 1) benzene, 5 h, reflux, 2) MeOH, THF, 3 h, reflux View Scheme
参考文献
Journet, Michel; Malacria, Max
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3085 - 3093
反应条件
copper(l) iodide; L-prolinol; tetrakis(triphenylphosphine) palladium(0) in water T=25°C; Sonogashira coupling; 3 h; Product distribution; Further Variations:Temperatures;
参考文献
Kundu, Nitya G.; Pal, Manojit; Mahanty, Jyan S.; De, Mahuya
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2815 - 2820
反应条件
potassium hydroxide; tetra-(n-butyl)ammonium iodide 3 h;
参考文献
Soldatov; Ripmeester; Shergina; Sokolov; Zanina; Gromilov; Dyadin
Journal of the American Chemical Society, 1999 , vol. 121, # 17 p. 4179 - 4188
反应条件
potassium hydroxide; magnesium sulfate in diethylene glycol dimethyl ether; pentane
参考文献
The Dow Chemical Company
Patent: US4215127 A1, 1980 ;
参考文献
Pudowik
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1462,1467; engl. Ausg. S. 1593, 1598
反应条件
sodium hydroxide; ammonium chloride; copper(l) chloride in water T=55°C; 10 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 31, # 1.1 p. 52 - 56
Zhurnal Organicheskoi Khimii, , vol. 31, # 1 p. 58 - 63
反应条件
sodium hydroxide; ammonium chloride; copper(l) chloride in water T=44.9°C; 10 h; ΔH (excit.), ΔS (excit.) and ΔG (excit.); other alkenyl halides, other reagents; var. temps.; Thermodynamic dataKinetics;
参考文献
Russian Journal of Organic Chemistry, , vol. 31, # 1.1 p. 52 - 56
Zhurnal Organicheskoi Khimii, , vol. 31, # 1 p. 58 - 63
反应条件
maleic anhydride; tributylphosphine; bis(ν5-cyclooctadienyl)ruthenium; hydroquinone in acetic acid; toluene T=80°C; 5 h;
参考文献
Mitsudo, Take-aki; Hori, Yoji; Yamakawa, Yasushi; Watanabe, Yoshihisa
Journal of Organic Chemistry, 1987 , vol. 52, # 11 p. 2230 - 2239
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940 , p. 219
Chem.Abstr., 1942 , p. 746
