2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: 1.) n-butyllithium; 2.) mercurous chloride, cuprous chloride / 1.) hexane, THF, -78 deg C, 1 h; 2.) hexane, THF, -78 deg C --> room temp., then reflux, 5.5 h
2: 1.) EtMgBr / 2.) CuCl / 1.) THF, 50 deg C, 30 min; 2.) THF, 50-55 deg C, 2 h
3: 77 percent / potassium hydroxide / methanol / 16 h / 0 °C
View Scheme
参考文献
Scott,L.T.; Decicco,G.J.; Huyn,J.L.
Journal of the American Chemical Society, 1985 , vol. 107, p. 6546
反应条件
pyridine; diethyl ether; phosphorus trichoride
参考文献
Air Reduction Co.
Patent: US2728791 , 1954 ;
参考文献
Air Reduction Co.
Patent: US2728791 , 1954 ;
反应条件
piperidine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine
4 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: US2008/194552 A1, 2008 ;
Location in patent: Page/Page column 43 ;
US 20080194552 A1
反应条件
copper(l) iodide; diisopropylamine; triphenylphosphine; palladium dichloride in N,N-dimethyl-formamide
T=60°C; 24 h;
参考文献
Paegle, Edgars; Belyakov, Sergey; Arsenyan, Pavel
European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3831 - 3840
反应条件
1: phosphorus (III)-chloride
2: diethyl ether
View Scheme
参考文献
Moulin
Helvetica Chimica Acta, 1951 , vol. 34, p. 2416,2417,2426
反应条件
copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride in triethylamine
Sonogashira coupling reaction; 6 h; Heating;
参考文献
Lee, Sang Ho; Nakamura, Toshikazu; Tsutsui, Tetsuo
Organic Letters, 2001 , vol. 3, # 13 p. 2005 - 2007
反应条件
copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=20°C; 14 h;
参考文献
Van Steenis, Dirk Jan V. C.; David, Olivier R. P.; Van Strijdonck, Gino P. F.; Van Maarseveen, Jan H.; Reek, Joost N. H.
Chemical Communications, 2005 , # 34 p. 4333 - 4335
反应条件
piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=20°C; Sonogashira coupling; 2 h;
参考文献
Zeng, Xianshun; Wang, Changsheng; Bryce, Martin R.; Batsanov, Andrei S.; Sirichantaropass, Skon; Garcia-Suarez, Victor M.; Lambert, Colin J.; Sage, Ian
European Journal of Organic Chemistry, 2007 , # 31 p. 5244 - 5249
反应条件
copper(l) iodide; ethanolamine; triphenylphosphine; palladium on activated charcoal in water
T=80°C; Sonogashira coupling; 8 h;
参考文献
Raju, Sirisilla; Kumar, P. Rajender; Mukkanti; Annamalai, Pazhanimuthu; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6185 - 6189
