5-氨基-3-氰基-1-(2,6-二氯-4-三氟甲基苯基)吡唑合成路线 （共 20 条）
反应条件
ammonia in ethanol; water T=0°C; 0.166667 h;
参考文献
Aventis Agriculture Ltd.
Patent: US6392081 B1, 2002 ;
Location in patent: Page column 9 ;
反应条件
1: 2,6-dichloro-4-(trifluoromethyl)-benzenamine With sulfuric acid; sodium nitrite in acetic acid T=55 - 60°C; 0.666667 h; 2: CH2(CN)CH(CN)CO2Et in water; acetic acid T=5 - 20°C; 3: With ammonium hydroxide in dichloromethane T=20°C;
参考文献
Zhao, Qiqi; Li, Yongqiang; Xiong, Lixia; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 8 p. 4992 - 4998
反应条件
2,6-dimethylpyridine in methanol T=20 - 25°C;
参考文献
BASF SE; DOCHNAHL, Maximilian; SUKOPP, Martin; KORTE, Alexander
Patent: WO2010/105969 A1, 2010 ;
Location in patent: Page/Page column 11-12 ;
反应条件
in chloroform T=20 - 50°C; 3.5 h;
参考文献
Bayer CropScience S.A.
Patent: EP1378506 A1, 2004 ;
Location in patent: Page 4 ;
参考文献
Aventis CropScience S.A.
Patent: US6620944 B1, 2003 ;
反应条件
in 1,4-dioxane; hydrogenchloride; acetic acid
反应条件
1.1: dimethylsulfone; potassium fluoride; ammonia / 6 h / 30 - 235 °C / 18751.9 - 19502 Torr / |Autoclave 2.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C 3.1: nitrosyl-sulphuric acid; acetic acid / 30 - 55 °C 3.2: 0 - 15 °C View Scheme
反应条件
1: With hydrogenchloride; 2,6-dichloro-4-(trifluoromethyl)-benzenamine; sodium nitrite in 2-methoxy-ethanol 3 h; 2: pH=9;
参考文献
EP1264823 A1, ;
Example 2 ;
反应条件
1.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C 2.1: nitrosyl-sulphuric acid; acetic acid / 30 - 55 °C 2.2: 0 - 15 °C View Scheme
反应条件
disulfur dichloride in dichloromethane T=20°C;
参考文献
Zhao, Qiqi; Li, Yongqiang; Xiong, Lixia; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 8 p. 4992 - 4998
