10,11-二氢二苯并[a,b]环庚烯-5-酮合成路线 （共 77 条）
反应条件
hydrogenchloride; 1,1-dibromo ethane; magnesium 1) THF, reflux; 2) THF, reflux;; Yield given. Multistep reaction;
参考文献
Miodownik, A.; Kreisberger, J.; Nussim, M.; Avnir, D.
Synthetic Communications, 1981 , vol. 11, # 3 p. 241 - 246
反应条件
1: zinc-powder; ethanolic NaOH 2: SOCl2; pyridine; benzene View Scheme
参考文献
Arya,V.P. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 220 - 225
反应条件
in diethyl ether; water
参考文献
NOVO NORDISK A/S
Patent: EP585314 B1, 1996 ;
EP 0585314 B1
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.166667 h;
参考文献
Heterocycles, , vol. 82, # 2 p. 1633 - 1644
反应条件
hydrogenchloride; sodium hydroxide in methanol; ethanol; chloroform; water; carbon
参考文献
US4513002 A1, ;
US 4513002 A
反应条件
(i) Mg, (ii) /BRN= 1454355/, THF; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 27, p. 230 - 240
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium in tetrahydrofuran Heating; 2: 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one in tetrahydrofuran T=0 - 20°C; Grignard reaction; Further stages.;
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
反应条件
methanol in tetrahydrofuran; toluene T=20°C; Grignard Reaction; Flow reactor; TemperatureSolvent;
参考文献
Kupracz, Lukas; Kirschning, Andreas
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3375 - 3380
反应条件
sodium tetrahydroborate
参考文献
Pomerantz, Martin; Combs, Gerald L.; Fink, Rina
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 143 - 149
反应条件
magnesium 1) Et2O, THF 2) 3-5 deg C, 45 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Polivka, Zdenek; Holubek, Jiri; Budesinsky, Milos; Matousova, Oluse; Svatek, Emil; et al.
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 11 p. 2758 - 2774
