反应条件
1: 1.) diisopropylamine, BuLi / 1.) THF, hexane, a) -50 deg C, 15 min, b) RT, 1 h, 2.) -78 deg C, 3 h 2: H2 / 10percent Pd/C / tetrahydrofuran / 760 Torr / Ambient temperature 3: p-TsOH, / CHCl3 / Ambient temperature 4: Jones' reagent / acetone / 1 h / 10 °C 5: 84 percent / H2 / PtO2 / ethyl acetate / 48 h / 37503 Torr / Ambient temperature 6: 73 percent / CF3SO3H / CH2Cl2 / 2 h / 0 - 20 °C 7: 1.) 1 N KOH / 1.) dioxane, water, RT, 5 h, 2.) THF, HMPA, 24 h 8: 73 percent / p-toluenesulfonic acid / CH2Cl2 / 3 h / -10 - 20 °C 9: H2 / 10percent Pd/C / tetrahydrofuran / 4 h / 760 Torr / Ambient temperature 10: benzenesulfonylchloride, pyridine / 0 °C 11: 88 percent / pyridinium p-toluenesulfonate / ethanol / 2 h / 50 - 55 °C 12: 80 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Barbier; Schneider
Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202
