2-氨基-2-甲基-1-丙醇合成路线 （共 271 条）
参考文献
Pierce et al.
Journal of the American Chemical Society, 1942 , vol. 64, p. 2884
参考文献
Pfleiderer,W.; Zondler,H.
Chemische Berichte, 1966 , vol. 99, p. 3008 - 3021
反应条件
in acetonitrile T=20°C; Condensation;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2036896 A1, 2009 ;
Location in patent: Page/Page column 149 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 2 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/838 A1, 2003 ;
Location in patent: Page 71-72 ;
WO 2004/000838 A1
反应条件
in tetrahydrofuran; water
参考文献
Pfizer Inc.
Patent: US6284764 B1, 2001 ;
参考文献
Barton, Derek H. R.; Fekih, Abdelwaheb; Lusinchi, Xavier
Bulletin de la Societe Chimique de France, 1988 , # 4 p. 681 - 687
反应条件
sodium tetrahydridoborate in chloroform byproducts: methanol; Fe-contg. compd. (2.00 mmol) and 2-amino-2-methylpropan-1-ol (2.10 mmol)were dissolved in CHCl3 and the soln. was refluxed for 3 h under Ar; th e solvent was removed, the residue was dissolved in CH3OH; cooling in anice bath; B-contg. compd. addn.; the react. was terminated by addn. of aq. NaOH soln.; the mixt. was extd. with CH2Cl2; the exts. were washed with satd. aq. NaCl soln., dried over MgSO4 and evapd. under vac.; chromy. on short silica gel column (ethyl acetate as eluent); elem. anal.;
参考文献
Journal of Organometallic Chemistry, , vol. 689, # 3 p. 631 - 638
反应条件
in methanol T=40°C; 1 h;
参考文献
Dey, Mishtu; Pulla Rao, Chebrolu; Saarenketo, Pauli; Rissanen, Kari; Kolehmainen, Erkki
European Journal of Inorganic Chemistry, 2002 , # 8 p. 2207 - 2215
参考文献
Cordelle, Cindy; Agustin, Dominique; Daran, Jean-Claude; Poli, Rinaldo
Inorganica Chimica Acta, 2010 , vol. 364, # 1 p. 144 - 149
反应条件
toluene-4-sulfonic acid in toluene Heating;
参考文献
Gaber, Abd El-Aal M.; Hunter, Gordon A.; McNab, Hamish
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 548 - 554
