N-Boc-3,4-二氢-2H-吡啶合成路线 （共 23 条）
反应条件
1: 79 percent / DMAP / acetonitrile 2: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3: 86 percent / p-TsOH / toluene / 0.33 h View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
参考文献
Tetrahedron Letters, , vol. 42, # 31 p. 5167 - 5170
反应条件
caesium carbonate in dimethyl sulfoxide T=120°C;
参考文献
Kovackova, Sona; Dracinsky, Martin; Rejman, Dominik
Tetrahedron, 2011 , vol. 67, # 7 p. 1485 - 1500
反应条件
(THF)W(CO)5 in tetrahydrofuran r.t., 20 h then reflux, 2 d;
参考文献
McDonald, Frank E.; Chatterjee, Arnab K.
Tetrahedron Letters, 1997 , vol. 38, # 44 p. 7687 - 7690
反应条件
1: With palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether T=20°C; 0.0833333 h; Inert atmosphere; 2: With formic acid; triethylamine in ethylene glycol dimethyl ether T=85°C; 0.666667 h; Inert atmosphere;
参考文献
Gigant, Nicolas; Dequirez, Geoffroy; Retailleau, Pascal; Gillaizeau, Isabelle; Dauban, Philippe
Chemistry - A European Journal, 2012 , vol. 18, # 1 p. 90 - 94
反应条件
1: dichloromethane / 4 h / 20 °C 2: anhydrous iron chloride; 4-(N,N-dimethlyamino)pyridine; di-tert-butyl peroxide / 1,2-dichloro-ethane / 18 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 15, # 8 p. 1918 - 1921
反应条件
sec.-butyllithium 1) THF, -78 deg C, 5 min, 2) THF, -78 deg C to RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1109 - 1117
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 3.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 20°C; 3.25 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/140320 A1, 2009 ;
Location in patent: Page/Page column 77 ;
WO 2009/140320 A1
