4,4-二甲基-1-苯戊烷-1,3-二酮合成路线 （共 34 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=50°C; 1 h;
参考文献
Nandurkar, Nitin S.; Bhanushali, Mayur J.; Patil, Dinkar S.; Bhanage, Bhalchandra M.
Synthetic Communications, 2007 , vol. 37, # 23 p. 4111 - 4115
反应条件
hydrogenchloride in N,N-dimethyl-formamide
4 h; Ambient temperature;
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: 48 percent / (phenylethylamino)magnesium bromide
2: 93 percent / conc. H2SO4 / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Sosnovskikh, V. Ya.; Kostrikova, T. P.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 4 p. 790 - 791
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 4 p. 883 - 884
反应条件
1: 69 percent / Et3N / CH2Cl2 / cooling
2: 99 percent / MgBr2*OEt2; iPr2NEt / CH2Cl2 / 4 h
View Scheme
参考文献
Lim, Daniel; Fang, Fang; Zhou, Guoqiang; Coltart, Don M.
Organic Letters, 2007 , vol. 9, # 21 p. 4139 - 4142
反应条件
1: 81 percent / DCC / dioxane
2: 81 percent / MgBr2*OEt2; iPr2NEt / CH2Cl2 / 24 h
View Scheme
参考文献
Lim, Daniel; Fang, Fang; Zhou, Guoqiang; Coltart, Don M.
Organic Letters, 2007 , vol. 9, # 21 p. 4139 - 4142
反应条件
methylene bis(iodozinc) in tetrahydrofuran
T=25°C; Grob type fragmentation; Inert atmosphere;
参考文献
Sada, Mutsumi; Furayama, Taniyuki; Komagawa, Shinsuke; Uchiyama, Masanobu; Matsubara, Seijiro
Chemistry - A European Journal, 2010 , vol. 16, # 34 p. 10474 - 10481
反应条件
diethyl ether; sodium amide
参考文献
Levine; Sneed
Journal of the American Chemical Society, 1951 , vol. 73, p. 5614
反应条件
1: 48 percent / (phenylethylamino)magnesium bromide
2: 93 percent / conc. H2SO4 / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Sosnovskikh, V. Ya.; Kostrikova, T. P.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 4 p. 790 - 791
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 4 p. 883 - 884
反应条件
1: tetrahydrofuran
2: 62 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1: 83 percent / 1.) 1N NaOH, 2.) cc. HCl / H2O / Ambient temperature
2: tetrahydrofuran
3: 62 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
