3,5-二叔丁基-4-羟基苯甲醛合成路线 （共 132 条）
反应条件
1: NH2OH*HCl, Py / ethanol; methanol / Heating 2: H2SO4 / Heating View Scheme
参考文献
Mueller,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 645, p. 36 - 52
反应条件
piperidine in pyridine 1.5 h; Heating;
参考文献
Vol'eva; Belostotskaya; Komissarova; Kurkovskaya
Russian Journal of Organic Chemistry, 2008 , vol. 44, # 6 p. 803 - 806
反应条件
piperidine in ethanol T=50 - 60°C; 4 h;
参考文献
Katsumi; Kondo; Fuse; Yamashita; Hidaka; Hosoe; Takeo; Watanabe
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1619 - 1627
反应条件
sodium acetate in pyridine T=180 - 190°C; Perkin reaction; 3 h;
参考文献
Vol'eva; Belostotskaya; Komissarova; Kurkovskaya
Russian Journal of Organic Chemistry, 2008 , vol. 44, # 6 p. 803 - 806
反应条件
acetic acid in methanol; ethyl acetate; toluene
参考文献
WARNER-LAMBERT COMPANY
Patent: EP245825 B1, 1991 ;
反应条件
piperidine; acetic acid in toluene 24 h; Heating;
参考文献
Flynn; Belliotti; Boctor; Connor; Kostlan; Nies; Ortwine; Schrier; Sircar
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 518 - 525
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 2 h, 2.) RT, 8 h 2: 69 percent / methanol. HCl / 24 h / Heating 3: molybdenum hexacarbonyl, H2O / acetonitrile / 12 h / Heating 4: 97percent hydrazine, acetic acid / 12 h / Ambient temperature View Scheme
参考文献
Flynn; Belliotti; Boctor; Connor; Kostlan; Nies; Ortwine; Schrier; Sircar
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 518 - 525
反应条件
piperidine in dichloromethane
T=140°C; 2.5 h;
参考文献
Lazer, Edward S.; Wong, Hin-Chor; Possanza, Genus J.; Graham, Anne G.; Farina, Peter R.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 100 - 104
反应条件
in dichloromethane; ethyl acetate
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US4743606 A1, 1988 ;
反应条件
1: 47 percent / piperidine, p-toluenesulfonic acid / ethanol / 48 h / Heating
2: 60 percent / 2 N NaOH / ethanol / 4 h / Heating
View Scheme
参考文献
Lazer, Edward S.; Wong, Hin-Chor; Possanza, Genus J.; Graham, Anne G.; Farina, Peter R.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 100 - 104
