N,N-二乙基苯甲酰胺合成路线 （共 244 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium; iodine; mercury dichloride
1.) THF, hexane, 1 h, 20 deg C; Yield given. Multistep reaction;
参考文献
Eaton, Philip E.; Martin, Ronald M.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2728 - 2732
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Eaton, Philip E.; Martin, Ronald M.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2728 - 2732
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether
1.) -78 deg C, 1 h, 2.) -78 deg C -> RT, 12 h;
参考文献
Watanabe; Snieckus
Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1457 - 1460
反应条件
hydrogenchloride; N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h; Yield given. Multistep reaction;
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
1.1: sec-butyllithium; tetramethylethylenediamine / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran
1.3: 82 percent / silica gel / toluene / Heating
2.1: 100 percent / Zn; CuSO4 / aq. NH3 / 24 h / Heating
3.1: acetic acid / zinc chloride / Heating
4.1: MeOH; NaHCO3
4.2: 58 percent / CrO3; silica gel / CH2Cl2 / 20 °C
View Scheme
参考文献
Starling, Sergia M.; Raslan, Delio S.; De Oliveira, Alaide B.; Zani
Synthetic Communications, 1998 , vol. 28, # 19 p. 3567 - 3578
反应条件
Yield given. Multistep reaction;
参考文献
Iwao, Masatomo; Kuraishi, Tsukasa
Tetrahedron Letters, 1985 , vol. 26, # 50 p. 6213 - 6216
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1.) THF, -78 deg C, 1h, 2.) -78 deg C; Yield given. Multistep reaction;
参考文献
Beak, Peter; Brown, Roger A.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 34 - 46
反应条件
1: 1.) s-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.a) THF, -78 deg C, 30 min, b) r.t., 2 h
2: benzene / 12 h / Ambient temperature
3: MeSO3H / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Watanabe; Ijichi; Furukawa
Synthesis, 1993 , # 1 p. 94 - 98
反应条件
dipotassium peroxodisulfate; silver nitrate in water; acetonitrile
T=90°C; 1 h; regioselective reaction;
参考文献
Mao, Xuerong; Ma, Xiao; Zhang, Shuwei; Hu, Hongwen; Zhu, Chengjian; Cheng, Yixiang
European Journal of Organic Chemistry, 2013 , # 20 p. 4245 - 4248
反应条件
phosphorus pentachloride
T=120 - 130°C; Zersetzung des Reaktionsprodukts durch Wasser;
参考文献
v. Braun; Pinkernelle
Chemische Berichte, 1934 , vol. 67, p. 1218
