N,N-二甲基环己烷羧酰胺合成路线 （共 20 条）
反应条件
1: in toluene T=65°C; Schlenk techniqueInert atmosphere; 2: With bromine in toluene T=-78°C; 0.0333333 h; Schlenk techniqueInert atmosphere; 3: With water in toluene T=20°C; 1 h; Schlenk techniqueInert atmosphere; regioselective reaction;
参考文献
Synthetic Communications, , vol. 43, # 21 p. 2955 - 2965
反应条件
1: methyl-phenyl-thioether With 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: cyclohexanecarboxylic acid dimethylamide With PhMe2SiLi in tetrahydrofuran; hexane T=-78°C; 2 h;
参考文献
Buswell, Marina; Fleming, Ian; Ghosh, Usha; Mack, Stephen; Russell, Matthew; Clark, Barry P.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3006 - 3017
反应条件
diethyl ether; LiAlH2(OEt)2
参考文献
Brown; Tsukamoto
Journal of the American Chemical Society, 1959 , vol. 81, p. 502
反应条件
tert-butyl alcohol in tetrahydrofuran electrolysis (Mg electrodes, LiClO4);
参考文献
Shono, Tatsuya; Masuda, Haruhisa; Murase, Hiroaki; Shimomura, Masatoshi; Kashimura, Shigenori
Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1061 - 1063
反应条件
sodium (tert-butylamino)trihydroborate in tetrahydrofuran T=66°C; 65 h; further reducing agent: sodium (dimethylamino)trihydroborat (NaDMAB); Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 49, # 13 p. 2438 - 2443
反应条件
diethyl ether; ethyl-lithium T=-20°C;
参考文献
Izzo; Safir
Journal of Organic Chemistry, 1959 , vol. 24, p. 701
反应条件
1: in toluene T=65°C; Schlenk techniqueInert atmosphere; 2: With N-bromosuccinmide in toluene T=-78°C; Schlenk techniqueInert atmosphere; 3: With water in toluene T=20°C; 1 h; Schlenk techniqueInert atmosphere; regioselective reaction;
参考文献
Kobeissi, Marwan; Cherry, Khalil; Jomaa, Wissam
Synthetic Communications, 2013 , vol. 43, # 21 p. 2955 - 2965
反应条件
in water
T=0°C; 1 h;
参考文献
Buswell, Marina; Fleming, Ian; Ghosh, Usha; Mack, Stephen; Russell, Matthew; Clark, Barry P.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3006 - 3017
反应条件
dimethyl amine; triethylamine in tetrahydrofuran; ethanol; chloroform
参考文献
SMITH KLINE and FRENCH LABORATORIES, LIMITED
Patent: EP385686 A3, 1992 ;
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
T=-55°C; Substitution; transacylation;
参考文献
Hans, Jeremy J.; Driver, Russell W.; Burke, Steven D.
Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 2114 - 2121
