1,6-二氧螺环[4.4]-壬烷合成路线 （共 33 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane 0.0333333 h; Ambient temperature;
参考文献
Torok, Daniel S.; Figueroa, John J.; Scott, William J.
Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 7274 - 7276
反应条件
salicylic acid resin supported FeCl3 in benzene T=90 - 104°C; 2 h;
参考文献
Huirong, Yang; Yingde, Li Bina Cui
Synthetic Communications, 1998 , vol. 28, # 7 p. 1233 - 1238
反应条件
K10; montmorillonite in toluene T=40 - 60°C; P=11251.1 Torr; 0.166667 h; Inert atmosphere; Product distribution / selectivity;
参考文献
SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.; BOS, Alouisius Nicolaas Renee; DERKS, Willem
Patent: WO2011/830 A1, 2011 ;
Location in patent: Page/Page column 10-12; 5/7; 7/7 ;
反应条件
1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C 2: conc. aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Kita, Yasuyuki; Yasuda, Hitoshi; Haruta, Jun-ichi; Segawa, Jun; Tamura, Yasumitsu
Synthesis, 1982 , # 12 p. 1089 - 1091
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature; Yield given;
参考文献
Kita, Yasuyuki; Yasuda, Hitoshi; Haruta, Jun-ichi; Segawa, Jun; Tamura, Yasumitsu
Synthesis, 1982 , # 12 p. 1089 - 1091
反应条件
1.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / methanol / 3 h / |Reflux 3.1: sulfuric acid / 25 h / 20 - 25 °C 4.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 4.2: 1.5 h / |Reflux; |Inert atmosphere 4.3: 4.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
tetrachlorosilane; KU-2 (H+) cation exchange resin T=100°C; 4 h; other chlorosilane reagent; Product distribution;
参考文献
Mullakhmetova, Z. F.; Nedogrei, E. P.; Musavirov, R. S.; Kantor, E. A.; Rakhmankulov, D. L.
J. Gen. Chem. USSR (Engl. Transl.), 1986 , vol. 56, # 1 p. 229 - 230,205 - 206
反应条件
Product distribution;
参考文献
Bauduin, G.; Bondon, D.; Pietrasanta, Y.; Pucci, B.
Tetrahedron, 1980 , vol. 36, # 2 p. 245 - 254
反应条件
D20 T=225°C; 0.5 h; Yield given;
参考文献
Kuhlmann, Barbara; Arnett, Edward M.; Siskin, Michael
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3098 - 3101
反应条件
Product distribution;
参考文献
Bauduin, G.; Bondon, D.; Pietrasanta, Y.; Pucci, B.
Tetrahedron, 1980 , vol. 36, # 2 p. 245 - 254
