1,6-二氧螺环[4.4]-壬烷合成路线 （共 33 条）
反应条件
Product distribution;
参考文献
Bauduin, G.; Bondon, D.; Pietrasanta, Y.; Pucci, B.
Tetrahedron, 1980 , vol. 36, # 2 p. 245 - 254
反应条件
bromine in 1,4-dioxane T=10 - 15°C; 1.5 h;
参考文献
Marchand, Alan P.; Reddy, Sivakumar D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4078 - 4080
反应条件
hydrogenchloride T=150°C; 2 h;
参考文献
Doklady Chemistry, , vol. 284, p. 319 - 321
Dokl. Akad. Nauk SSSR Ser. Khim., , vol. 284, # 5 p. 1151 - 1154
反应条件
hydrogenchloride T=150°C; 2 h;
参考文献
Musavirov, R. S.; Mullakhmetova, Z. F.; Nedogrei, E. P.; Kantor, E. A.; Rakhmankulov, D. L.; Paushkin, Ya. M.
Doklady Chemistry, 1985 , vol. 284, p. 319 - 321
Dokl. Akad. Nauk SSSR Ser. Khim., 1985 , vol. 284, # 5 p. 1151 - 1154
反应条件
1.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / methanol / 3 h / |Reflux 3.1: sulfuric acid / 25 h / 20 - 25 °C 4.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 4.2: 1.5 h / |Reflux; |Inert atmosphere 4.3: 4.5 h / |Reflux; |Inert atmosphere 5.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux 6.1: sodium hydroxide / methanol; tetrahydrofuran / 14 h / 20 °C View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
methyl iodide in toluene T=80 - 90°C; 12 h;
参考文献
Iwata, Arihiro; Tang, Heqing; Kunai, Atsutaka; Ohshita, Joji; Yamamoto, Yasushi; Matui, Chinami
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5170 - 5175
反应条件
1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 2: sodium hydroxide / methanol / 3 h / |Reflux 3: sulfuric acid / 25 h / 20 - 25 °C View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
indium(III) chloride in 1,2-dichloro-ethane 0.2 h; Heating;
参考文献
Ranu, Brindaban C.; Das, Arijit; Samanta, Sampak
Synlett, 2002 , # 5 p. 727 - 730
反应条件
2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one in chloroform T=20°C; 0.416667 h;
参考文献
Iranpoor, Nasser; Firouzabadi, Habib; Shaterian, Hamid Reza; Zolfigol
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 5 p. 1047 - 1071
反应条件
1.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / methanol / 3 h / |Reflux 3.1: sulfuric acid / 25 h / 20 - 25 °C 4.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 4.2: 1.5 h / |Reflux; |Inert atmosphere 4.3: 4.5 h / |Reflux; |Inert atmosphere 5.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
