4-溴-N-Boc-哌啶合成路线 （共 13 条）
反应条件
1: NaN3 / dimethylformamide / 20 °C 2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr 3: DIPEA / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
N,N,N',N,-tetramethylethylenediamine; PdCl2(amphos)2; zinc in water
T=20°C; Negishi-like cross-coupling; 24 h; Inert atmosphere;
参考文献
Krasovskiy, Arkady; Thome, Isabelle; Graff, Julien; Krasovskaya, Valeria; Konopelski, Paul; Duplais, Christophe; Lipshutz, Bruce H.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2203 - 2205
反应条件
4-ethyl-pyridine; manganese; sodium tetrafluoroborate; 1,10-phenanthroline; [NiCl2(1,2-dimethoxyethane)] in methanol
T=60°C; 18 h; Inert atmosphere;
参考文献
Molander, Gary A.; Traister, Kaitlin M.; ONeill, Brian T.
Journal of Organic Chemistry, 2014 , vol. 79, # 12 p. 5771 - 5780
