2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
参考文献
SARCODE BIOSCIENCE INC.; ZELLER, James, Robert; VENKATRAMAN, Sripathy; BROT, Elisabeth, C.A.; IYER, Subashree; HALL, Michael
Patent: WO2014/18748 A1, 2014 ;
Location in patent: Paragraph 00136; 00137 ;
反应条件
oxygen 1 h; Irradiation;
参考文献
Puyau, P. de Macedo; Perie, J. J.
Phosphorus, Sulfur and Silicon and the Related Elements, 1997 , vol. 129, p. 13 - 46
反应条件
T=20 - 110°C; Michaelis-Arbuzov reaction; 24 h; Inert atmosphereneat (no solvent);
参考文献
Camper, Nicolas; Scott, Christopher J.; Migaud, Marie E.
New Journal of Chemistry, 2010 , vol. 34, # 5 p. 949 - 955
反应条件
1: 1.) LDA, HMPT / 1.) hexane, THF, 0 deg C, 20 min, 2.) -50 deg C, 4 h 2: 70 percent / 1.5M aq. tartaric acid / 2 h / 0 °C View Scheme
参考文献
Grigorieva, N. Ya.; Yudina, O. N.; Moiseenkov, A. M.
Synthesis, 1989 , # 8 p. 591 - 595
反应条件
Yield given. Multistep reaction;
参考文献
Grigor'eva, N. Ya.; Yudina, O. N.; Daeva, E. D.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 1.1 p. 76 - 84
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 1 p. 89 - 97
反应条件
magnesium in tetrahydrofuran 1 h; Effect of temperature is investigated. Amount of Buchi's Grignard reagent (1) is changed.; MechanismProduct distribution;
参考文献
Sworin, Michael; Neumann, William L.
Tetrahedron Letters, 1987 , vol. 28, # 28 p. 3217 - 3220
反应条件
acetic acid; lithium diisopropyl amide
2.) 115 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chelucci, Giorgio; Cossu, Sergio; Scano, Gianfranco; Soccolini, Francesco
Heterocycles, 1990 , vol. 31, # 8 p. 1397 - 1403
反应条件
1: 1,3-Dithiane With n-butyllithium
Metallation;
2: 2-(1,3-dioxa-2-cyclopentyl)-ethyl bromide Alkylation;
参考文献
Wilken, Joerg; Winter, Martin; Stahl, Ingfried; Martens, Juergen
Tetrahedron Asymmetry, 2000 , vol. 11, # 5 p. 1067 - 1071
反应条件
in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=-78 - 0°C;
参考文献
Burke, Steven D.; Powner, Tory H.; Kageyama, Masanori
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4529 - 4532
反应条件
1: 2-(1,3-dioxa-2-cyclopentyl)-ethyl bromide With iodine; magnesium; ethylene dibromide in tetrahydrofuran
1 h;
2: methyl chloroformate in tetrahydrofuran
T=-78 - 20°C;
参考文献
Liu, Xuan; West
Chemical Communications, 2006 , # 48 p. 5036 - 5038
