3-(二甲基氨基)-4'-溴苯丙酮合成路线 （共 7 条）
反应条件
conc. iHCl in ethanol T=90°C; Mannich reaction; 24 h;
参考文献
Stocking, Emily M.; Miller, Jennifer M.; Barbier, Ann J.; Wilson, Sandy J.; Boggs, Jamin D.; McAllister, Heather M.; Wu, Jiejun; Lovenberg, Timothy W.; Carruthers, Nicholas I.; Wolin, Ronald L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3130 - 3135
反应条件
1: vinyl-magnesium bromide; N-methoxy-N-methyl-p-bromobenzamide in tetrahydrofuran 2: dimethyl amine in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 18 p. 5567 - 5571
参考文献
Journal of the Chemical Society, , p. 4092 - 4096
反应条件
n-butyllithium in diethyl ether; hexane 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h;
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 51 percent / 1.) BuLi / diethyl ether; hexane / 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h 2: conc. H2SO4, Ac2O / 0.5 h / Heating View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 24 h / Ambient temperature
2: KOH / CH2Cl2; H2O / 0.17 h
3: 2 h / Ambient temperature
4: 95 percent / oxalic acid / H2O / 9 h / Ambient temperature
5: 58 percent / NH2OH*HCl / aq. ethanol / 18 h / Heating; other reagent : NH3(g) + CH3COONH4
View Scheme
参考文献
Pavlyuchenko, A. I.; Purvanyatskas, G. V.; Smirnova, N. I.; Titov, V. V.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 7 p. 1375 - 1378
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 7 p. 1524 - 1529
反应条件
1: 51 percent / 1.) BuLi / diethyl ether; hexane / 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h
2: conc. H2SO4, Ac2O / 0.5 h / Heating
3: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
4: 41 percent / dimethylformamide / 3 h / 80 °C
5: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
