反应条件
1: 4-methoxy-benzoic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide 0.25 h; 2: 1-amino-3-cyanobenzene in N,N-dimethyl-formamide T=20 - 80°C; 54 h;
参考文献
MERCK PATENT GMBH; SUTTON, Amanda E.; RICHARDSON, Thomas E.; HUCK, Bayard R.; KARRA, Srinivasa R.; CHEN, Xiaoling; XIAO, Yufang; GOUTOPOULOS, Andreas; LAN, Ruoxi; PERREY, David; VANDEVEER, Harold, George; LIU-BUJALSKI, Lesley; STIEBER, Frank; HODOUS, Brian L.; QIU, Hui; JONES, Reinaldo C.; HEASLEY, Brian
Patent: WO2010/93419 A1, 2010 ;
Location in patent: Page/Page column 186-187; 296 ;
WO 2010/093419 A1