2,2,-二甲基-2H-苯并吡喃合成路线 （共 66 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=150°C; 15 h;
参考文献
Mannhold, Raimund; Cruciani, Gabriele; Weber, Horst; Lemoine, Horst; Derix, Andrea; Weichel, Claus; Clementi, Monica
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 981 - 991
反应条件
3-Methylpyridine in xylene
T=118°C; 24 h;
参考文献
North, Jeffrey T.; Kronenthal, David R.; Pullockaran, Annie J.; Real, Sharon D.; Chen, Helen Y.
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3397 - 3400
反应条件
propionic acid; 3,4,5-trimethoxyphenylboronic acid in anhydrous xylene
72 h; Molecular sieveReflux;
参考文献
De Boer, Johannes W.; Browne, Wesley R.; Harutyunyan, Syuzanna R.; Bini, Laura; Tiemersma-Wegman, Theodora D.; Alsters, Paul L.; Hage, Ronald; Feringa, Ben L.
Chemical Communications, 2008 , # 32 p. 3747 - 3749
反应条件
in 1,2-dichloro-ethane
T=70°C; 26 h;
参考文献
Efe, Christina; Lykakis, Ioannis N.; Stratakis, Manolis
Chemical Communications, 2011 , vol. 47, # 2 p. 803 - 805
反应条件
1: With ytterbium(III) triflate in dichloromethane
T=20°C; 60 h;
2: With toluene-4-sulfonic acid in toluene
1 h; Heating;
参考文献
Prado, Soizic; Janin, Yves L.; Bost, Pierre-Etienne
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1605 - 1608
反应条件
1: 98 percent / PPh3, CuI / PdCl2 / triethylamine; dimethylformamide / 1.5 h / 50 °C
2: 54 percent / BBr3 / CH2Cl2 / 0.08 h / 0 °C
3: 63 percent / 30percent KOH / ethanol; H2O / 4 h / 90 °C / Heating
View Scheme
参考文献
Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru
Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
反应条件
1: NaBH4 / methanol / 20 °C
2: p-TsOH*H2O / toluene / 22 h / 100 °C
View Scheme
参考文献
Gerlach; Brendel; Lang; Paulus; Weidmann; Brueggemann; Busch; Suessbrich; Bleich; Greger
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3831 - 3837
反应条件
1: 98 percent / PPh3, CuI / PdCl2 / triethylamine; dimethylformamide / 1.5 h / 50 °C
2: 54 percent / BBr3 / CH2Cl2 / 0.08 h / 0 °C
3: 63 percent / 30percent KOH / ethanol; H2O / 4 h / 90 °C / Heating
View Scheme
参考文献
Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru
Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
反应条件
1: 70 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 8 h / 80 °C
2: H2 / Raney Ni / methanol / 20 °C
3: K2CO3 / acetone / 70 °C
4: 75 percent / TsOH*H2O / toluene / Heating
5: 5percent aq. NaOH / methanol / 50 °C
6: DDQ / benzene / 80 °C
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: H2 / Raney Ni / methanol / 20 °C
2: K2CO3 / acetone / 70 °C
3: 75 percent / TsOH*H2O / toluene / Heating
4: 5percent aq. NaOH / methanol / 50 °C
5: DDQ / benzene / 80 °C
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
