1,4-二溴-2,5-二甲氧基苯合成路线 （共 25 条）
反应条件
nachfolgend Methylierung;
参考文献
Kohn; Guttmann
Monatshefte fuer Chemie, 1924 , vol. 45, p. 582
参考文献
Kohn; Steiner
Chemische Berichte, 1931 , vol. 58, p. 92,101
反应条件
1: 2,5-dibromo-1,4-dimethoxybenzene With isopropylmagnesium chloride in tetrahydrofuran T=25°C; 20 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran
参考文献
Gothard, Chris M.; Nowick, James S.
Journal of Organic Chemistry, 2010 , vol. 75, # 6 p. 1822 - 1830
反应条件
1: Reaktion ueber mehrere Stufen 2: ethanolic KOH-solution View Scheme
参考文献
Luettringhaus; Gralheer
Justus Liebigs Annalen der Chemie, 1942 , vol. 550, p. 67,83
反应条件
bromine; iodine in tetrachloromethane Heating;
参考文献
Hart, Harold; Lai, Chung-yin; Nwokogu, Godson Chukuemaka; Shamouilian, Shamouil
Tetrahedron, 1987 , vol. 43, # 22 p. 5203 - 5224
反应条件
1: BBr3 / CH2Cl2 / 0 - 20 °C 2: 48.4 percent / potassium carbonate / acetone / 72 h / Heating View Scheme
参考文献
Liu, Bin; Yu, Wang-Lin; Lai, Yee-Hing; Huang, Wei
Macromolecules, 2002 , vol. 35, # 13 p. 4975 - 4982
反应条件
1: 2,5-dibromo-1,4-dimethoxybenzene With n-butyllithium; N,N-dimethyl-formamide in diethyl ether; hexane T=0°C; 0.416667 h; 2: N,N-dimethyl-formamide in hexane 0.166667 h; Heating; Further stages.;
参考文献
Layton, Mark E.; Morales, Carl A.; Shair, Matthew D.
Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 773 - 775
反应条件
1: 1.) ZnCl2, 2.) Pd(PPh3)4 / 1.) THF, -78 deg C, 1 h; room temperature, 1 h, 2.) THF, 55 deg C, 12 h 2: 80 percent / CAN / H2O; acetonitrile / 0.08 h View Scheme
参考文献
Palmgren, Andreas; Thorarensen, Atli; Baeckvall, Jan-E.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3764 - 3768
反应条件
1: 2,5-dibromo-1,4-dimethoxybenzene With n-butyllithium in tetrahydrofuran T=-78°C; 2: (4-morpholinyl)methanone in tetrahydrofuran T=-78°C;
参考文献
Hwang, Gil Tae; Son, Hyung Su; Ku, Ja Kang; Kim, Byeang Hyean
Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11241 - 11248
反应条件
1: 2,5-dibromo-1,4-dimethoxybenzene With n-butyllithium in tetrahydrofuran T=-80°C; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-80°C;
参考文献
Tylleman, Benoit; Velde, Christophe M.L. Vande; Balandier, Jean-Yves; Stas, Sara; Sergeyev, Sergey; Geerts, Yves Henri
Organic Letters, 2011 , vol. 13, # 19 p. 5208 - 5211
