3beta-乙酰氧基-19-羟基雄甾-5-烯-17-酮合成路线 （共 8 条）
反应条件
zinc in acetic acid T=45°C; 1 h; Yield given;
参考文献
MEDEXIS S.A.; ALEVIZOPOULOS, Konstantinos; CALOGEROPOULOU, Theodora
Patent: WO2012/13816 A1, 2012 ;
Location in patent: Page/Page column 94 ;
WO 2012/013816 A1
参考文献
Richardson-Merrell Inc.
Patent: US4071625 A1, 1978 ;
反应条件
lead(IV) acetate; (R)-bromo alcohol; zinc Yield given. Multistep reaction;
参考文献
Terasawa; Okada
Tetrahedron, 1986 , vol. 42, # 2 p. 537 - 545
反应条件
boron trifluoride diethyl etherate
参考文献
Tanabe; Takasaki; Sakai; Hayashi; Morisawa
Chemical and pharmaceutical bulletin, 1967 , vol. 15, # 1 p. 15 - 27
反应条件
hydrogen; Pd/SrCO3 in ethanol
参考文献
Dauben,W.G.; Ben-Efraim,D.A.
Journal of Medicinal Chemistry, 1968 , vol. 11, p. 287 - 291
反应条件
chromium(VI) oxide; sulfuric acid in acetone
参考文献
Tanabe; Takasaki; Sakai; Hayashi; Morisawa
Chemical and pharmaceutical bulletin, 1967 , vol. 15, # 1 p. 15 - 27
反应条件
1: 69 percent / aq. HClO4, Tl(NO3)3*3H2O / dioxane / 0.25 h / Ambient temperature 2: 97 percent / KOH / methanol / 3 h / Ambient temperature 3: 78 percent / 1-methyl-4-piperidone, (i-PrO)3Al / toluene / 4 h / Heating 4: 96 percent / p-TsOH / diethyl ether / Ambient temperature View Scheme
参考文献
Kocovsky; Baines
Tetrahedron Letters, 1993 , vol. 34, # 38 p. 6139 - 6140
反应条件
lithium aluminium tetrahydride
参考文献
Berkoz,B. et al.
Steroids, 1963 , vol. 1, p. 251 - 270
