二乙基((1-氰乙基)磷酸盐合成路线 （共 9 条）
反应条件
1: anhydrous propionitrile With lithium diisopropyl amide in tetrahydrofuran; hexane; cyclohexane T=-78°C; 0.25 h; Inert atmosphere; 2: diethyl chlorophosphate in tetrahydrofuran; hexane; cyclohexane T=-78 - 20°C; 1.16667 h; Inert atmosphere;
参考文献
Sovdat, Tina; Bassolino, Giovanni; Liebel, Matz; Schnedermann, Christoph; Fletcher, Stephen P.; Kukura, Philipp
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8318 - 8320
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With sodium hydride in ethylene glycol dimethyl ether T=-10°C; Metallation; 0.75 h; 2: methyl iodide in ethylene glycol dimethyl ether T=-10 - 20°C; Methylation; 17.5 h;
参考文献
Simon, Joachim R.; Neidlein, Richard
Synthesis, 2000 , # 8 p. 1101 - 1108
参考文献
Raggio; Watt
The Journal of organic chemistry, 1976 , vol. 41, # 10 p. 1873 - 1875
参考文献
Pudowik; Lebedewa
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 2235,2237,2239;engl.Ausg.S.2199,2201,2202
反应条件
1,4-diaza-bicyclo[2.2.2]octane; Spirolt;cyclohexan-1,3'-oxaziridingt; in toluene 12 h; Ambient temperature;
参考文献
Andreae, Siegfried; Schmitz, Ernst; Wulf, Jens-Peter; Schulz, Burkhard
Liebigs Annalen der Chemie, 1992 , # 3 p. 239 - 256
反应条件
1: NaH / tetrahydrofuran / 3 h / Ambient temperature
2: 1.) oxone / 1.) acetone, H2O, RT, 30 min, 2.) 20 deg C, 3 d
View Scheme
参考文献
Defacqz, Nathalie; Touillaux, Roland; Marchand-Brynaert, Jacqueline
Journal of Chemical Research, Miniprint, 1998 , # 9 p. 2273 - 2286
反应条件
lithium hydroxide; 4 Angstrome MS in tetrahydrofuran
T=70°C; Horner-Wadsworth-Emmons olefination; 21 h;
参考文献
Lattanzi, Alessandra; Orelli, Liliana R.; Barone, Patrizia; Massa, Antonio; Iannece, Patrizia; Scettri, Arrigo
Tetrahedron Letters, 2003 , vol. 44, # 7 p. 1333 - 1337
参考文献
Freerksen, Robert W.; Selikson, Sandra J.; Wroble, Randall R.; Kyler, S. Keith; Watt, David S.
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4087 - 4096
反应条件
(i) NaH, 1,2-dimethoxy-ethane, (ii) /BRN= 507309/; Multistep reaction;
参考文献
Marshall,J.A.; Bierenbaum,R.
Journal of Organic Chemistry, 1977 , vol. 42, # 20 p. 3309 - 3311
