反应条件
1.1: sodium hydroxide / water; acetonitrile / 12 h / 0 - 45 °C 1.2: pH 6 2.1: sodium tetrahydroborate; iodine; methanol / tetrahydrofuran / 2 h / 0 - 5 °C / |Reflux 3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C 4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere 5.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 5.2: 0.25 h / -5 °C / |Inert atmosphere 5.3: 0.08 h 6.1: methyl iodide / water; methanol / 0.5 h / 20 °C / |Cooling with ice 6.2: pH 3 - Ca. 7 / |Reflux 7.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 7.2: pH 2 - 3 View Scheme
参考文献
ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.; Pan, Xianhua; Li, Weijin; Zhang, Qunhui; Ruan, Libo; Yu, Wansheng; Deng, Fei; Ma, Tianhua; Huang, Mingwang; He, Minhuan
Patent: US2013/281695 A1, 2013 ;
